About this opportunity:
As part of the Structural Biology team, you will be working as part of multi-disciplinary project teams, providing critical support for the structure-based design (SBD) of agrochemicals. This opportunity requires significant experience in solving protein structures by X-ray crystallography, with utilisation of other techniques such as NMR or cryo-EM an advantage. This work is also complemented by the use of biophysical methods such as ITC but experience of this can be gained in the role.
Role purpose:
- To solve protein structures using the most suitable method to inform the design of further compounds along the research pipeline
- To help guide the production of suitable protein for structural studies by working closely with Protein Science colleagues
- Facilitate collaborations both internally and externally to address issues related to accessing certain protein families for structural work
- Effectively coordinate and communicate timely results through presentations, e-mails and reports
Qualifications
Required:
- PhD in a structural biology related discipline
- Practical experience of protein crystallization, optimisation, X-ray data collection and structure solution ideally across a number of protein families
Desirable Experience (any of):
- Soluble and/or membrane protein expression and purification
- Other structure solution methods such as cryo-EM or NMR
- Biophysical methods such as ITC, DSF and SPR
- Screening methods such as XChem for fragments, assays for in vitro campaigns, etc.
- Use of molecular biology and structure prediction analysis software
- Basic chemistry knowledge in the area of protein:ligand interactions
Additional Information
In return for your skills and knowledge Syngenta will offer:
- Vibrant and research-orientated campus environment
- Competitive benefits package
- Up to 31.5 days holiday per annum plus bank holidays
- The opportunity to work with and learn from highly qualified and experienced employees
- Good onsite facilities including a staff restaurant, a gym and fitness classes.
- A modern, stimulating and dynamic working environment which promotes diversity and inclusion, scientific excellence and collaboration.
We embrace and encourage diversity, and this is what drives our innovation and lets us outperform the market. https://www.syngenta.com/careers/working-syngenta/diversity-and-inclusion
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Company Description
Syngenta Group is one of the world’s leading sustainable agriculture innovation companies, with roots going back more than 250 years. Our 53,000 people across more than 100 countries strive every day to transform agriculture through tailor-made solutions for the benefit of farmers, society and our planet – making us the world’s most local agricultural technology and innovation partner.
As a world market leader in crop protection, we help farmers to counter these threats and ensure enough safe, nutritious, affordable food for all – while minimizing the use of land and other agricultural inputs. Syngenta Crop Protection keeps plants safe from planting to harvesting. From the moment a seed is planted through to harvest, crops need to be protected from weeds, insects and diseases as well as droughts and floods, heat and cold. Syngenta Crop Protection is headquartered in Switzerland.
Crop protection is a core component of the Syngenta business, with significant product portfolios covering all the major agricultural sectors. R&D is imperative to providing new solutions for our customers and Syngenta employs 5,000 R&D scientists globally. Jealott’s Hill International Research Centre in Berkshire is Syngenta’s largest R&D site, employing over 800 people who are actively supporting crop protection lead discovery, optimisation, development and registration.
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